TABLE 1.

Functional and conformational characterization

	Relative amidolytic activity	Relative proteolytic activity	Relative carbamylation rate	Relative antithrombin inhibition rate
Wild-type	1.0	1.0	1.0	1.0
FVIIaD212N	2.0 ± 0.2	0.3 ± 0.0	0.5 ± 0.1	1.8 ± 0.04
FVIIaDVQ	6.2 ± 0.6	25 ± 3.4a	0.1 ± 0.1	4.9 ± 0.6
FVIIaK161A	0.2 ± 0.0	0.2 ± 0.0	NDb	ND
FVIIaD217A	0.5 ± 0.1	0.4 ± 0.0	ND	ND
FVIIaD219A	0.6 ± 0.0	0.5 ± 0.0	ND	ND

^aValue from Ref. 20.

^bND, not determined.