TABLE 5.
Effect of mevinolin and fosmidomycin on accumulation of polyisoprenoid alcohols and sterols Values represent mean ± S.D. of three experiments performed in triplicate. d.w. indicates dry weight.
|
Age of culture |
Polyisoprenoid alcohols |
Sterols |
||||
|---|---|---|---|---|---|---|
| No inhibitor | Mevinolin | Fosmidomycin | No inhibitor | Mevinolin | Fosmidomycin | |
| days | μg/g d.w. | % control | μg/g d.w. | % control | ||
| 7 | 12.0 ± 2.1 | 133.3 ± 16.5 | 26.7 ± 7.5 | 2522 ± 100 | 76.2 ± 5.1 | 22.2 ± 4.5 |
| 14 | 23.9 ± 3.1 | 20.9 ± 4.6 | 150.0 ± 16.1 | 2769 ± 152 | 42.3 ± 4.4 | 111.0 ± 11.1 |
| 21 | 27.9 ± 2.9 | 15.4 ± 9.6 | 225.2 ± 27.5 | 3271 ± 220 | 18.0 ± 3.5 | 133.1 ± 12.3 |