Table 1.

Amino acids reported by ICM PocketFinder to contribute to the binding pockets of open-to-out DAT, NET and SERT

	DAT	NET	SERT
TMH1	F76, A77, D79, L80 A81, W84, R85, Y88	F72, A73, D75, L76, A77, W80, R81, Y84	Y95, A96, D98, G100, W103, R104, Y107, I108
TMH3	V152, F155, Y156, I159	145, V148, Y151, Y152, I155, W158	A169, I172, A173, Y175, Y176, I179, W182
TMH6	F320, S321, G323, F326, V328	F317, S318, G320, F323, V325	F335, L336, L337, G338, F341, V343
EL4	V382, A383, K384, D385, G386, P387, L389, I390	A380, E382, G383, A384, L386, V387, F388	A398, K399, D400, A401, P403, L405, L406, F407
TMH8	S422, A423, G426	S419, S420, G423	S438, T439, G442
TMH10	F472, D476, A480	G465, I466, L469, T470	E493, T497