Table 3.
Chemotherapy compliance after lobectomy by different approach
| VATS n = 54 |
Thoracotomy n = 56 |
p value | |
|---|---|---|---|
| Chemotherapy regimens, no. (%) | 0.577 | ||
| Gemcitabine+Cisplatin | 25 (46.3) | 29 (51.8) | |
| Paclitaxol+Carboplatin | 22(40.7) | 23(41.1) | |
| Vinorelbine+Cisplatin | 7(13.0) | 4(7.1) | |
| Time to initiate chemotherapy(days) | 33.7 ± 10.9 | 34.0 ± 13.3 | 0.904 |
| Cycles completed, (Mean ± SD) | 3.6 ± 0.72 | 3.0 ± 1.1 | 0.002* |
| Pts. Receive full dose on schedule, no. (%) | 31 (57.4) | 19 (33.9) | 0.013 |
| Pts. Receive ≥75% planed dose, no. (%) | 48(88.9) | 40(71.4) | 0.022* |
| Mean doses, (% of planed) | |||
| Cisplatin (mg/m2) | 267 (89.0) | 237 (79.0) | 0.121 |
| Gemcitabine (mg/m2) | 8900 (9.0) | 7930 (79.3) | 0.120 |
| Paclitaxol (mg/m2) | 620 (88.6) | 495 (70.7) | 0.020* |
| Carboplatin (AUC mg/ml/min) | 21.3 (88.8) | 17.0 (70.8) | 0.019* |
| Toxicity, no. (%) | 0.011* | ||
| Grade 1/2 toxicity | 25 (46.3) | 34 (60.7) | 0.130 |
| Grade 3/4 toxicity | 11 (20.4) | 20 (35.7) | 0.074 |