Table 1.
Comparison between K562 Gleevec-treated group versus K562 control group.
| A. K562 Gleevec-treated group versus K562 control group | |||
|---|---|---|---|
| Function | Enrichment Score | Enrichment p-value | # genes in list, in group |
| KEGG JAK STAT SIGNALING PATHWAY | 12.616000 | 0.000003 | 8 |
| ST STAT3 PATHWAY | 6.219490 | 0.001990 | 2 |
| B. JAK-STAT Signaling Pathway | |||
| Gene Symbol | Definition | p-value(K562 Treated vs. K562 Control) |
Fold-Change (K562 Treated vs. K562 Control) |
| BCL2L1 | Homo sapiens BCL2-like 1 (BCL2L1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA. | 0.000076 | -2.336810 |
| CISH | Homo sapiens cytokine inducible SH2-containing protein (CISH), mRNA. | 0.000754 | -2.926860 |
| CCND1 | Homo sapiens cyclin D1 (CCND1), mRNA. | 0.000964 | -9.480380 |
| SPRED1 | Homo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1), mRNA. | 0.001425 | -3.138930 |
| SOCS1 | Homo sapiens suppressor of cytokine signaling 1 (SOCS1), mRNA. | 0.003518 | -2.455500 |
| IL6 | Homo sapiens interleukin 6 (interferon, beta 2) (IL6), mRNA. | 0.004541 | -2.036640 |
| PIK3CG | Homo sapiens phosphoinositide-3-kinase, catalytic, gamma polypeptide (PIK3CG), mRNA. | 0.005740 | -2.292180 |
| PIM1 | Homo sapiens pim-1 oncogene (PIM1), mRNA. | 0.006760 | -2.343000 |
(a) Gene set analysis showing enrichment of gene sets under JAK/STAT pathway. These gene sets showed the number of genes that are downregulated in this pathway in K562 Gleevec-treated cells. (b) List of downregulated genes related to JAK/STAT pathway in K562 Gleevec-treated cells