Fig. 2.

The frequency of paw withdrawal in response to acetone before and at several time points after surgery in the saline-treated CCI group, saline-treated sham group, and drug-treated CCI group. Nefopam (10, 20, and 30 mg/kg (A)), Nimesulide (1.25, 2.5, and 5 mg/kg (B)), morphine (1, 3, and 5 mg/kg (C)) were injected i.p. Results are expressed as the mean ± SEM of 8 animals per group. Nef: Nefopam, Nim: Nimesulide, Mor: Morphine. Asterisks indicate a significant difference between post surgery days compared with day 0 (^*P < 0.05, ^†P < 0.01, ^‡P < 0.001).