Fig. 3.

Paw withdrawal threshold in response to von Frey filaments (A) and the frequency of paw withdrawal in response to acetone (B) before and at several time points after surgery in saline-treated CCI group, saline-treated sham group and drug-treated CCI groups in combination: (morphine 3 mg/kg + nefopam 10 mg/kg, morphine 3 mg/kg + nimesulide 1.25 mg/kg, nimesulide 1.25 mg/kg + nefopam 10 mg/kg) were injected i.p. Results are expressed as the mean ± SEM of 8 animals per group. Nef: Nefopam, Nim: Nimesulide, Mor: Morphine. Asterisks indicate a significant difference between post surgery days compared with day 0 (^*P < 0.01, ^†P < 0.001).