Table.
| Disease | Cell type | Result | Reference |
|---|---|---|---|
| Inflammation (NSAID- and Schistosoma-induced intestinal inflammation) | Intestine (mouse) | Vanin 1-/- mice ↑ GSH and γ-GCS vs. WT + cysteamine negated effect. | Martin et al. 2004 |
| Inflammation (Colitis) | Gut epithelial cells (mouse) | Vanin 1-/- mice ↑ PPARγ mRNA and protein vs. WT. + cysteamine negated effect. | Berruyer et al. 2006 |
| Inflammation (Psoratic skin) | Differentiated keratinocytes (human) | ↑ Vanin 1/Vanin 3 mRNA after addition of Th1 cytokines. | Jensen et al. 2009 |
| Malaria (Inflammation and Oxidative stress) | Spleen, Liver, Blood (mouse) | Vanin 1-/- Vanin 3-/- mice ↑ susceptibility to malaria. + cystamine: ↓ mortality, ↓ blood paresitemia. | Min-Oo et al. 2007 |
| Carcinogenesis (Inflammation-driven colorectal cancer) | Gut epithelial cells (mouse) | Vanin 1-/- mice: 70% ↓ in tumours and ↓ NF-κβ vs. WT. | Pouyet et al. 2010 |
| Huntington's Disease | Brain (mouse) | + cysteamine: ↓ TGase, ↓abnormal movements and prolonged survival. | Karpuj et al. 2002 |
| Huntington's Disease | Cultured astrocytes | + cysteamine: partial suppression of cell death and ↓ cleavage of caspase-3. | Ientile et al. 2003 |
| Wound Healing | Dermal fibroblasts (human) | + pantothenic acid: ↑ number of fibroblasts, ↑ speed and distance travelled. | Weimann et al. 1999 |
| Type 1 diabetes (Drug-induced and auto immune diabetes) | Pancreatic islet cells and kidney capsules | Pancreas: Vanin 1-/- ↑ incidence diabetes ↑ number of cleaved caspase-3 positive cells ↑ susceptibility to death compared to wt. | Roisin-Bouffay et al. 2008 |
| Lipedemia | Blood | + pantethine or + cysteamine ↓ TG, LDL, ApoB ↑ HDL-C and ApoA + pantothenic acid, no change. |
Wittwer et al. 1987 |