Table 3.
Replication genotyping of selected SNPs in the FIND sample
| Adjustment | SNP | CHR | Gene | A1 | P-value | OR | Model | P (3SNP)b | OR (3SNP)b | P-1a | OR-1a |
|---|---|---|---|---|---|---|---|---|---|---|---|
| age, sex, and global admixture | rs136148 | 22q12.3 | APOL1 | C | 1.92E-05 | 0.50 | Dom | 0.013 | 0.62 | 2.06E-02 | 0.62 |
| rs2239785 | 22q12.3 | APOL1 | A | 5.03E-21 | 0.32 | Dom | 9.14E-13 | 0.33 | 5.18E-05 | 0.52 | |
| rs4821480 | 22q12.3 | MYH 9 | C | 2.91E-11 | 2.25 | Rec | 1.31E-05 | 1.91 | |||
| age, sex, and global and local admixture at MYH9 | rs136148 | 22q12.3 | APOL1 | C | 6.54E-04 | 0.57 | Dom | 0.021 | 0.64 | 4.10E-02 | 0.65 |
| rs2239785 | 22q12.3 | APOL1 | A | 6.07E-17 | 0.34 | Dom | 1.12E-10 | 0.35 | 1.75E-04 | 0.53 | |
| rs4821480 | 22q12.3 | MYH 9 | C | 5.78E-07 | 1.97 | Rec | 3.40E-03 | 1.61 |
Abbreviations and definitions: A1, ???; FIND, Family Investigation of Nephropathy in Diabetes; CHR = chromosomal location, Dom = dominant model, Rec = recessive model, OR = odds ratio; rs, reference single-nucleotide polymorphism identification number; SNP, single-nucleotide polymorphism
a
P-1 and OR-1 are results from association analysis with adjustment for the APOL1 G1/G2 risk alleles.
b
OR (3SNP) and P (3SNP) are analyses adjusted for the other two SNPs