. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Neurobiol Dis. 2011 Oct 17;45(2):683–691. doi: 10.1016/j.nbd.2011.10.009

Table 1.

Levels of proteins in the hippocampus of 3-month-old 2N and Ts65Dn mice by Western blot. Numbers of mice for each group are shown in brackets. Mean ± SEM.

Protein	Band, kDa	2N	Ts65Dn	p
GABAAα1	49	95.5 ± 4.0 (12)	84.3 ± 5.3 (10)	0.09
GABAAα2	55	93.2 ± 7.8 (12)	93.3 ± 9.9 (10)	0.99
GABAAα3	56	100.2 ± 4.7 (11)	99.7 ± 7.6 (8)	0.95
GABAAα5	55	50.0 ± 1.3 (12)	45.8 ± 3.1 (10)	0.17
GABAAγ2	48	167.6 ± 3.6 (12)	168.4 ± 6.4(10)	0.91
GABAB1a	130	36.3 ± 3.4 (5)	35.3 ± 4.8 (5)	0.85
GABAB1b	105	80.7 ± 7.4 (5)	88.9 ± 2.0 (5)	0.27
Kir3.2	43	35.0 ± 3.1 (9)	55.7 ± 4.3 (9)*	<0.001
GAT-1	72	38.7 ± 2.2 (12)	41.0 ± 2.9 (10)	0.49
Actin	42	96.8 ± 4.8 (11)	95.6 ± 7.9 (8)	0.88

Note a significant increase in the level of Kir3.2 subunits of potassium channels in Ts65Dn samples. Levels the GABAA and GABAB receptor subunits and GABA transporter 1 were not changed.