. Author manuscript; available in PMC: 2013 Jan 1.

Published in final edited form as: Trends Pharmacol Sci. 2011 Oct 17;33(1):28–34. doi: 10.1016/j.tips.2011.09.002

Table 2.

Roles of small GTPases in anterograde transport of GPCRs

GTPases	Regulated steps	GPCRs	GTPase binding	Refs
Rab family
Rab1	ER-to-Golgi	(Table 1)
Rab2	Between ER and Golgi	α_2B-AR		[24]
		β₂-AR
Rab6	Between ER and Golgi	β₂-AR		[24]
		AT1R
Rab8	Golgi-to-cell surface	α_2B-AR	CT	[31]
		β₂-AR	CT: LL motif
Sar1/ARF family
Sar1	ER exit	α_2B-AR		[44]
		β₂-AR
		AT1R
		hCaR		[45]
ARF1	ER-to-Golgi and Golgi-to-cell surface	α_2B-AR	CT	[47]
	ER-to-Golgi and Golgi-to-cell surface	β₂-AR
		AT1R
		CXCR4
		M3-MR
ARF3	Unknown	α_2B-AR		[47]
ARF4	Post-Golgi	Rhodopsin	CT: VxPx motif	[49,50]
ARF5	Unknown	α_2B-AR		[47]
ARF6	ER-to-cell surface	V2R	Receptor	[53]
		V1a-R
		M2-MR
		α_2B-AR		[47]

CT, C terminus.