. Author manuscript; available in PMC: 2013 Jan 1.

Published in final edited form as: Eur J Med Chem. 2011 Nov 4;47C:167–174. doi: 10.1016/j.ejmech.2011.10.039

Table 1.

Pd(PPh₃)₄ Catalyzed Cross-Coupling of 6 with organozinc halides followed by treatment with NH₃/MeOH

Entry	RZnX	Product, R	Yield %
1	MeZnBr	7, CH₃	95
2	EtZnBr	8, CH₂CH₃	82
3	n-PrZnBr	9, CH₂CH₂CH₃	86
4	n-BuZnBr	10, CH₂(CH₂)₂CH₃	89
5	isoBuZnBr		88
6	cycloPrZnBr		92
7	cycloBuZnBr		78
8	cyclopentylZnBr		60
9	PhZnBr		78
10	2-ThienylZnBr		80