Table 2.
Serum fatty acid status and adjusted odds ratios of suicide death
| Suicide Deaths (n=800) | Matched Controls (n=800) | Odds Ratioa | |||
|---|---|---|---|---|---|
| Fatty Acid | Mean (SD) | Mean (SD) | Odds Ratio (95% CI) | P Value | |
| Omega-3 Polyunsaturated Fatty Acids | |||||
| ALAb | 18:3n-3 | 0.54 (0.23) | 0.55 (0.25) | 1.05 (0.95–1.18) | ns |
| EPAb | 20:5n-3 | 0.44 (0.16) | 0.45 (0.17) | 1.10 (0.99–1.23) | 0.08 |
| 22:5n-3 | 0.48 (0.13) | 0.48 (0.13) | 1.03 (0.93–1.15) | ns | |
| DHAb | 22:6n-3 | 1.14 (0.45) | 1.19 (0.47) | 1.14 (1.02–1.27) | 0.03 |
| Omega-6 Polyunsaturated Fatty Acids | |||||
| LAb | 18:2n-6 | 31.19 (4.04) | 31.39 (4.01) | 1.04 (0.94–1.15) | ns |
| 18:3n-6 | 0.40 (0.17) | 0.41 (0.16) | 1.08 (0.97–1.20) | ns | |
| 20:2n-6 | 0.25 (0.05) | 0.26 (0.05) | 1.10 (0.99–1.22) | ns | |
| 20:3n-6 | 1.61 (0.38) | 1.68 (0.37) | 1.18 (1.06–1.32) | 0.001 | |
| AAb | 20:4n-6 | 7.18 (1.87) | 7.29 (1.96) | 1.03 (0.93–1.15) | ns |
| 22:4n-6 | 0.32 (0.08) | 0.32 (0.08) | 1.01 (0.91–1.12) | ns | |
| 22:5n-6 | 0.23 (0.06) | 0.24 (0.07) | 1.03 (0.93–1.15) | ns | |
| Monounsaturated Fatty Acids | |||||
| 16:1n-7 | 1.60 (0.68) | 1.51 (0.61) | 0.89 (0.81–0.99) | 0.04 | |
| 18:1n-9 | 22.95 (3.64) | 22.55 (3.71) | 0.93 (0.84–1.03) | ns | |
| 18:1n-7 | 2.48 (0.52) | 2.41 (0.56) | 0.88 (0.80–0.98) | 0.03 | |
| 20:1n-9 | 0.17 (0.05) | 0.17 (0.05) | 0.95 (0.88–1.05) | ns | |
| 24:1n-9 | 1.16 (0.35) | 1.15 (0.34) | 0.97 (0.88–1.09) | ns | |
| Saturated Fatty Acids | |||||
| 14:0 | 0.38 (0.26) | 0.41 (0.29) | 1.08 (0.97–1.19) | ns | |
| 16:0 | 18.44 (2.76) | 18.29 (2.91) | 0.94 (0.85–1.04) | ns | |
| 18:0 | 6.82 (0.96) | 7.01 (0.93) | 1.18 (1.05–1.30) | 0.003 | |
| 20:0 | 0.33 (0.06) | 0.33 (0.06) | 1.04 (0.94–1.15) | ns | |
| 22:0 | 1.03 (0.26) | 1.05 (0.27) | 1.08 (0.97–1.19) | ns | |
| 24:0 | 0.85 (0.21) | 0.87 (0.22) | 1.06 (0.96–1.18) | ns | |
a
Odds ratio of suicide death per one standard deviation (SD) for each fatty acid, adjusted for race/ethnicity and service component using multivariate logistic regression. Cases (n=800) and controls (n=800) were matched for sex, age, rank and date of blood draw. Fatty acids expressed as percent total serum fatty acids. ns indicates non-significant.
b
alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), linoleic acid (LA), arachidonic acid (AA).