Fig. 2.

Cerebellar defects in Lama1^CKO mice. Sagittal sections of adult control (A) and Lama1^CKO mice at 8 weeks age (B) were stained with Luxol Fast Blue. The cerebellum of Lama1^CKO mice is smaller than that of control mice, and the formation of some folia is disrupted. (a–c) High magnification view of areas indicated. In Lama1^CKO mice, the aggregation of granule cells in the molecular layer was observed under meninges of the cerebellar surface and fusion lines of folia (arrows). The meninges, which form the fissure of the folia, were completely lacking (asterisk). mcl, molecular cell layer; gcl, granule cell layer; wm, white matter; m, meninges. Black scale bars: 1.0 mm, White scale bars: 100 μm.