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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Trends Biochem Sci. 2011 Nov 11;37(1):15–22. doi: 10.1016/j.tibs.2011.10.002

Figure 1.

Figure 1

The ATM protein kinase. The C-terminal PI3 kinase-like kinase domain (KD), spanning aa ~2712 to 2962, is flanked by the domains FAT (FRAP, ATM and TRRAP; ~ aa 1960 to 2566) and FATC (FRAP, ATM and TRRAP C-terminal; ~ aa 2963 to 3056). The N-terminal region of the FATC domain has also been termed the “PIKK-regulatory domain” [5]. The location of autophosphorylation sites in ATM (S367, S1893, S1981 and S2996) [12, 24, 87] is shown. The N-terminus of ATM is composed of HEAT (Huntingtin, elongation factor 1A, protein phosphatase 2A A-subunit, TOR) repeats [88].