Local spread |
•Local spread into adjacent structures (e.g. pancreas, colon, spleen) |
Lymph node spread |
•Perigastric: pericardial; lesser curvature; greater curvature; suprapyloric |
•Extraperigastric: left gastric; common hepatic; coeliac; splenic hilum and artery; hepatic pedicle; retropancreatic; mesenteric root; middle colic; para-aortic |
Haematogenous spread |
•Most commonly the liver (25% at presentation) and peritoneum |
Notes |
•Transcoelomic spread can occur through the peritoneum (e.g. Kruckenberg tumours) |
•Retropancreatic, para-aortic and mesenteric nodes are classified as M1 metastatic disease |
•Nodal disease in GIST tumours is extremely rare |