Table 2.
Peak correlations between [11C]PIB tracer uptake and CSF BACE1 activity.
| Region | x | y | z | Z-score | Cluster |
|---|---|---|---|---|---|
| Parahippocampal gyrus (r), BA 35 | 18 | −24 | −9 | 3.91 | 733 |
| Parahippocampal gyrus (l), BA 28 | −24 | −24 | −6 | 3.58 | 372 |
| Parahippocampal gyrus (l), BA 35 | −14 | −13 | −28 | 3.51 | 235 |
| Thalamus (r) | 2 | −19 | 3 | 3.02 | 733 |
| Pons (r) | 8 | −20 | −38 | 3.12 | 495 |
Significant brain clusters were labeled in Talairach daemon software (talairach.org/Daemon.html) after conversion of MNI (bic.mni.mcgill.ca) to Talairach's coordinates using the Matlab function mni2tal (http://imaging.mrc-cbu.cam.ac.uk/imaging/MniTalairach); brain regions are indicated by Talairach's coordinates; cluster: extent of contiguous voxels within the cluster; r: right, l: left; BA: Brodmann's area.