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AMD3100 and T140 inhibit the SDF-1-induced chemotaxis of myeloid leukemia cells, and trigger the internalization of surface CXCR4. (A) Four-hour transmigration of MO7e cells towards SDF-1 (200 ng/mL). AMD3100 and T140 were added at concentrations of 10-5 M and 10-6 M, respectively. a)P<0.05, compared to the control. (B) U937 cells were incubated with or without 10-5 M AMD3100 and 10-6 M T140, respectively, for 3 hr and subsequently subjected to flow cytometry.
