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Survival of leukemia cells in an extended period of culture. (A) HL-60 cells (a), K562 cells (b), KG1a cells (c), and U937 cells (d) were incubated with AMD3100 (10-7 M to 10-5 M) for up to 14 days. Data are representative results of 3 or more independent experiments showing similar results. (B) Effects of AMD3100 on the formation of tumor cell colonies were examined using K562 cells. Representative profiles of the colony assay are shown.
