FIGURE 1.
THC and CBD inhibit CaV3 calcium channels. Recordings of recombinant human CaV3 channels stably expressed in HEK293 cells were made as outlined under “Experimental Procedures.” Each trace represents the current elicited by a voltage step from -86 mV to -26 mV under control conditions and in the presence of 1 μm THC (A, CaV3.1; B, CaV3.2; C, CaV3.3) or CBD (D, CaV3.1; E, CaV3.2; F, CaV3.3). An example of the time course of inhibition and degree of reversibility for THC and CBD inhibition of CaV3.1 are illustrated in A and D, respectively. The data are representative of at least six cells for each experiment.