FIGURE 7.
CBD affects the inactivation but not activation of CaV3 channels. The effects of CBD on activation and steady state inactivation of CaV3 currents are illustrated: i, CaV3.1; B, CaV3.2; C, CaV3.3. Cells were voltage-clamped at -106 mV. For steady state inactivation, cells were voltage-clamped at the test potential for 2 s before currents were evoked by a step to -26 mV. For steady state inactivation, data are presented as conductance normalized to conductance at -26 mV; for activation curves data are normalized to the maximum conductance. The data are fitted with a Boltzmann equation; the effects of CBD on activation and inactivation parameters are reported in Table 2. Each data point represents the mean ± S.E. of 6 cells.