FIGURE 8.
THC and CBD slow the recovery of CaV3.1 channels from inactivation. This effect is illustrated for THC (A) and CBD (B). Cells were voltage-clamped at -86 mV, stepped to -26 mV for 70 ms, and then retested with 10-ms steps to -26 mV at 10, 20, 40, 80, 160, 320, 640, 1280, and 2560 ms later. Each point represents the mean ± S.E. of 6 cells. Data were fitted with a single exponential function, and the half-time for recovery is shown. The half-time was significantly slowed (p < 0.01) by both CBD and THC.