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Thermodynamic parameters of the ING4-PHD/H3K4meX binding. The bar diagram shows the change in free energy (ΔG), enthalpy (ΔH), and in the contribution of entropy to the free energy (-TΔS) of the binding of H310K4meX peptides to ING4(188–249), as determined by ITC. The uncertainty in the experimental values is estimated to be ∼5%.
