TABLE 9.
EFFECT OF CHANGE IN AQUEOUS HUMOR PROFILE OF FOUR PROTEINS AND THE RESULTANT PATHOLOGIC CHANGES IN THE BUPHTHALMIC RABBIT
| PROTEIN | CHANGE IN AH | IHC | POSSIBLE MOLECULAR EVENT | HISTOLOGIC CORRELATE IN BUPHTHALMIC RABBIT | POSSIBLE FUNCTIONAL GROUP |
|---|---|---|---|---|---|
| Cochlin | Absent in 5-year-old BR | Increased TM IR | Impaired protein secretion | TM degeneration | Unknown mechanism causing elevated IOP |
| Interphotoreceptor retinoid-binding protein | Absent in 5-year-old BR | Generalized reduction in IR | Decreased synthesis or possible degradation by AH MMPs | TM degeneration | Retinoid deprivation |
| Haptoglobin | Reduced in 5-year-old BR | Reduction in IR at 5 years | Decreased synthesis | TM damage | Oxidative stress |
| Histidine-rich glycoprotein | Reduced at 2-year-old BR | Reduction in IR | Decreased synthesis | Increased DM thickness | Endothelial cell degeneration through apoptosis |
AH, aqueous humor; BR, buphthalmic rabbit; DM, Descemet’s membrane; IHC, immunohistochemistry; IOP, intraocular pressure; IR, immunoreactivity; TM, trabecular meshwork; MMPs, matrix metalloproteinases.