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. 2011 Nov 28;4:209–213. doi: 10.2147/IDR.S25408

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© 2011 Alavi et al, publisher and licensee Dove Medical Press Ltd.

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

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Possible mechanism for generation of plasmid R23. Transposon Tn1331 insertion into pPIGDM1 at the insertion site TATTA could lead to generation of pR23 plasmid. Two direct repeats of pentanucleotide TATTA flank inverted repeats (not shown) at the ends of Tn1331 transposon in pR23. Enterobacter plasmid pPIGDM1 carries an origin of replication (rep origin) in enterobacteria and the RNA one modulator (rom) gene, which helps maintain a low plasmid copy number. Tn1331 consists of genes coding for transposase (tnpA), resolvase (tnpR), aminoglycoside 6′-N-acetyltransferase type Ib (aac(6′)-Ib), Aminoglycoside (3″ adenylyltransferase (ant(3″)-Ia), oxacillinase-carbapenemases beta-lactamase (bla_OXA-9), partial coding sequence of resolvase (tnpR′), and TEM beta-lactamase (bla_TEM-1b). The Accession numbers for the coded proteins are TnpA: NP_608305.1, TnpR: NP_608306.1, AAC(6′)-Ib: NP_608307.1, ANT(3″)-Ia: NP_608308.1, OXA-9: NP_608309.2, and Bla-TEM-1b: NP_608310.1.