Table 4.
Studies analyzing the effect of NSAIDs on bone healing in humans.
| Study/Year | Design | NSAID used | Conclusions and recommendations |
|---|---|---|---|
| Davis and Ackroyd, 1988 [136] | Prospective double-blinded study of 100 patients with Colles' fracture | Fluriprophen (50 mg TDS) |
(i) No effect on Colles' fracture. |
|
| |||
| Adolphson et al., 1993 [137] | Randomized double-blinded study on 42 postmenopausal women with colles fracture | Piroxicam | (i) No decrease of the rate of fracture healing (ii) Patients receiving piroxicam had significantly less pain (iii) No difference in the rate of functional recovery |
|
| |||
| Butcher and Marsh, 1996 [138] | Retrospective review of 94 patients with tibial fracture | Not specified | (i) Increase in the length of time to union by of 7.6 weeks (P = 0.0003) (16.7 weeks versus 24.3 weeks). |
|
| |||
| Wurnig et al., 1999 [139] | 80 prospective patients receiving indomethacin prophylaxis for THR compared with 82 patients without | Indomethacin (Oral 50 mg BD) |
(i) No effect on prosthetic loosening after cementless hip arthroplasty |
|
| |||
| Giannoudis et al., 2000 [140] | Retrospective review of 377 patients treated with IM nail | Ibuprophen and Diclofenac | (i) Increased risk for nonunion in patients receiving NSAIDs |
|
| |||
| Bhandari et al., 2003 [141] | Retrospective review of 192 tibial shaft fractures | Not specified | (i) Relative risk of 2.02 (P = 0.035) for patient who take NSAIDs |
|
| |||
| Burd et al., 2003 [142] | Retrospective review of 282 with acetabular fractures | Indomethacin | (i) Patients receiving indomethacin had increased risk for developing non-union |
|
| |||
| Sculean et al., 2003 [143] | Randomized blindied study on 20 patients with deep intrabony defect | Rofecoxib (25 mg/day for 14 days) |
(i) No effect on the healing of intrabony periodontal defects |
|
| |||
| Bhattacharyya et al., 2005 [144] | Retrospective review of 9995 humeral shaft fractures treated nonoperatively | Not specified | (i) Exposure to nonselective NSAIDs in the period 61–90 days after a humeral shaft fracture was associated with nonunion |
|
| |||
| Meunier et al., 2009 [145] | Randomized study involving 50 patients undergoing total knee replacement | Celecoxib (200 mg BD) |
(i) No differences in prosthesis migration, pain scores, range of motion, and subjective outcome were found after 2 years |