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Apparent kinetic constants for insertion of divalent transition metals into 3 μm protoporphyrin IX in the presence of ferrochelatase
NA, not applicable.
|
Murine FC |
Yeast FC |
|||||
|---|---|---|---|---|---|---|
| Km | Ki | kcat | Km | Ki | kcat | |
| μm | μm | min-1 | μm | μm | min-1 | |
| Iron | 0.79 ± 0.19 | n/a | 6.6 ± 0.3 | 0.5 ± 0.1 | n/a | 45 ± 1 |
| Cobalt | 0.12 ± 0.04 | 22 ± 3 | 1.3 ± 0.1 | 0.2 ± 0.1 | 20 ± 10 | 11 ± 4 |
| Nickel | 1.1 ± 0.2 | 70 ± 10 | 1.3 ± 0.1 | 5.0 ± 0.5 | 74 ± 9 | 18 ± 1 |
| Zinc | NA | 12 ± 2 | 1.4 ± 0.1 | 0.19 ± 0.06 | 1.8 ± 0.4 | 23 ± 3 |
