Effect of Ac-SDKP on Blood Pressure, Infarct Size, Left Ventricular Weight, Myocyte Size, and Cardiac Function

	SBP (mm Hg)	HR (bpm)	IS (% LV)	LVW/BW (mg/10 g)	MCSA (μm2)	LVDd (mm)	EF (%)	E/A
Sham MI	115.2±2.5	346±8	...	17.0±0.2	205±4	5.9±0.1	59.6±3.1	1.64±0.06
MI–vehicle (2 mo)	110.5±3.2	334±11	42±2	20.5±0.4†	329±6†	8.5±0.2†	28.6±2.1†	2.35±0.22*
MI–vehicle (4 mo)	105.5±2.7	328±6*	42±2	19.7±0.5†	343±7†	8.0±0.1†	30.4±1.5†	2.24±0.13†
MI–Ac-SDKP (prevention)	104.1±4.4	314±28	44±3	20.2±0.3¶	326±7¶	8.9±0.4§	25.0±0.8‡	2.42±0.15¶
MI–Ac-SDKP (reversal)	113.9±3.1	331±7	45±3	19.6±0.3¶∥	312±11¶∥	7.9±0.2	31.8±1.3	2.25±0.16¶∥

SBP, indicates systolic blood pressure; HR, heart rate; IS, infarct size; LVW/BW, left ventricular weight/body weight; MCSA, myocyte cross-sectional area; LVDd, left ventricular diastolic dimension; EF, ejection fraction; E/A, ratio of E and A waves.

^*P<0.01 vs sham

^†P<0.001 vs sham

^‡P=0.004 vs MI-vehicle (4 months)

^§P=0.057 vs MI-vehicle (4 months).

^¶P=ns vs MI-vehicle (4 months)

^∥P=ns vs MI-vehicle (2 months).