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a, Somatic alterations identified in the ARID2 gene. *, nonsense mutations; #, frame-shifting indels; &, splice site mutation. b, ARID2 protein and the inactivating alterations (red arrows) Truncating mutations are indicated by red arrows. ARID, AT-rich interaction domain; RFX, RFX-like DNA binding motif; GLN, Proline-and glutamine-rich region; ZnF, C2H2 Zinc Fingers.
