Average % signal changes during encoding compared to baseline in (A) CA 2, 3, and dentate gyrus (CA23DG), (B) CA1, and (C) subiculum of genetic groups (APOE e3, n = 16; APOE e4, n = 16). Error bars correspond to the standard error across subjects for each group. APOE e3 carriers showed a significant increase in the left CA23DG compared to baseline and significantly higher percent signal change than APOE e4 carriers (APOE e3 > APOE e4, t(30) = 2.22; p < 0.05). Neither CA1 nor subiculum showed significant group differences.