Table 1. Demographic and Clinical Characteristics of the APOE e3 and APOE e4 groups.
There were no significant differences between age-matched APOE e3 and APOE e4 groups in memory-related performance as assessed by the Wechsler Memory Scale, Buschke-Fuld Selective Reminding test, and verbal-paired-associates task. Age and neuropsychological test values are reported as mean ± s.e.m.
| Characteristic | Range of Possible Scores * | APOE e3 Carriers (N=16) | APOE e4 Carriers (N=16) |
|---|---|---|---|
| Female sex – no. (%) | 12 (75.0) | 9 (56.3) | |
| Family history of dementia – no. (%) | 6 (37.5) | 9 (56.3) | |
| Years of age | 60.3 ± 1.9 | 61.9 ± 2.8 | |
| Years of education | 15.3 ± 1 | 17.1 ± 1 | |
| Logical Memory Delayed Recall portion of the Wechsler Memory Scale ∫ | 0–50 | 30.2 ± 1.7 | 26.8 ± 2.0 |
| Consistent Long-Term Retrieval portion of the Buschke-Fuld Selective Reminding Test ψ | 0–144 | 75.4 ± 8.1 | 71.1 ± 8.8 |
| Verbal-paired-associates task ς | 0–42 | 31.6 ± 1.3 | 34.3 ± 1.5 |
For standardized rating scales and memory tests, lower scores reflect poorer performance.
p = n.s. for the difference between groups. A score of 18.1 ± 6.0 is considered normal in this age group.
A score of 60.2 ± 32.4 for men and 71.4 ± 36.8 for women is considered normal in this age group.
This test was performed before fMRI scanning; seven pairs of unrelated words with the degree of recall assessed after each presentation. The total score reflects the total number of correct responses during retrieval for the six blocks.