TABLE 3.

Association of hematological status with TB recurrence among TB-infected patients in Tanzania¹

Hematological status2	Events, n/person-mo	Unadjusted model RR (95% CI)	Multivariate model RR (95% CI)3
All patients
No anemia or iron deficiency	24/5638	1.00	1.00
Iron deficiency without anemia	19/1646	2.00 (1.08, 3.67)	2.02 (0.96, 4.23)
Anemia without iron deficiency	14/871	2.71 (1.39, 5.27)	4.10 (1.88, 8.91)
Iron deficiency anemia	15/1044	2.20 (1.13, 4.25)	1.70 (0.71, 4.05)
HIV-infected patients4
No anemia or iron deficiency	7/2339	1.00	1.00
Iron deficiency without anemia	2/487	1.11 (0.23, 5.35)	2.11 (0.36, 12.46)
Anemia without iron deficiency	12/664	4.65 (1.82, 11.87)	6.68 (2.50, 17.83)
Iron deficiency anemia	11/704	3.61 (1.39, 9.38)	3.81 (1.26, 11.57)
HIV-uninfected patients4
No anemia or iron deficiency	17/3298	1.00	1.00
Iron deficiency without anemia	17/1159	1.92 (0.97, 3.81)	1.82 (0.80, 4.12)
Anemia without iron deficiency	2/207	1.43 (0.33, 6.24)	2.45 (0.50, 12.13)
Iron deficiency anemia	4/341	1.54 (0.51, 4.62)	0.68 (0.13, 3.44)

¹Hb, hemoglobin; MCV, mean corpuscular volume; TB, tuberculosis.

²Hematological status was categorized as no anemia or iron deficiency: Hb ≥110 g/L and MCV ≥80 fL; iron deficiency without anemia: Hb ≥110 g/L and MCV <80 fL; anemia without iron deficiency: Hb <110 g/L and MCV ≥80 fL; and iron deficiency anemia: Hb <110 g/L and MCV < 80 fL.

³Adjusted RR from a log-binomial regression model adjusting for sex, age (years via cubic splines), money spent on food (<500, ≥500 Tanzanian shillings spent/person/d), number of colonies in AFB culture (0, 1–100, >100 colonies), Karnfosky score (<70%, ≥70%), BMI (kg/m² via cubic splines), previous TB disease (yes/no), HIV status, CD4 cell count (cells/mm³ via cubic splines), log HIV RNA (copies/mm³ via cubic splines), malaria infection (yes/no), and trial regimen.

⁴P, test for interaction by HIV status = 0.24.