Fig. 4. Over-expression of Survivin significantly attenuated OxLDL-induced endothelial apoptosis.
(A) HAEC were infected with recombinant Survivin adenoviruses (Adv-Survivin) or GFP adenovirus (Adv-GFP, control) for 24 hours at different MOI. Survivin expression was measured by Western blot. (B) HAEC were infected with Adv-Survivin or Adv-GFP at MOI 100 for 24 hours and the cells were treated with or without 100 μg/ml of OxLDL. Over-expression of Survivin significantly inhibited OxLDL-induced apoptosis (* OxLDL+Survivin vs. OxLDL+GFP: p < 0.05, n=3).