Table 3.

Family-based association analysis between CXCR1/CXCR2 and VL

Common Designation	Allele	Allele frequency	# Fam	S	E(S)	Var(S)	Z	P
CXCR2_rs4674259	T	0.53	105	196	194	57.313	0.216	0.829
CXCR2_rs4674259	C	0.47	105	184	186	57.313	-0.216	0.829
CXCR1_rs2234671	G	0.85	69	181	165	31.519	2.935	0.003
CXCR1_rs2234671	C	0.15	69	61	77	31.519	-2.935	0.003
CXCR1_rs3138060	G	0.12	49	49	59	22.187	-2.222	0.026
CXCR1_rs3138060	C	0.88	49	133	122	22.187	2.222	0.026

Single point FBAT analysis under an additive model of inheritance for associations between CXCR1/CXCR2 polymorphisms and VL in the primary family-based sample set. # Fam = number of families informative for the FBAT analysis; S and E(S) represent the observed and expected transmissions for that allele, Var(S) is the variance. A positive Z score indicates association with disease; a negative Z score indicates the non-associated or protective allele or genotype. Bold indicates significant associations at nominal P ≤ 0.05. The corrected P-value required to achieve significance taking account of 3 independent SNPs is P ≤ 0.017.