Table 5.
Haplotype association analyses between CXCR1/CXCR2 and VL
| Haplo | Family Analysis | Freq | CXCR2_rs4674259 | CXCR1_rs2234671 | CXCR1_rs3138060 |
|---|---|---|---|---|---|
| T.G | TRANSMIT | 0.41 | χ2 = 4.61; 1df; P = 0.032 | ||
| _ G.C | TRANSMIT | 0.83 | χ2 = 10.27; 1df; P = 0.001 | ||
| T.G.C | TRANSMIT | 0.40 | χ2 = 5.98; 1df; P = 0.014 | ||
| Haplo | Case-Control | Freq | CXCR2_rs4674259 | CXCR1_rs2234671 | CXCR1_rs3138060 |
| T.G | PLINK | 0.43 | χ2 = 4.34; 1df; P = 0.037 | ||
| _ G.C | PLINK | 0.83 | χ2 = 1.29; 1df; P = 0.256 | ||
| T.G.C | PLINK | 0.42 | χ2 = 4.99; 1df; P = 0.025 | ||
Chi-squared (χ2), degrees of freedom (df) and P-values for risk associated (over-transmitted) haplotypes for the 3 SNPs as determined in TRANSMIT for the family-based primary sample, and in PLINK for the case-control replication sample. Bold indicates significant associations at nominal P ≤ 0.05. Haplotypes are called on the negative strand across the 3 SNPs.