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. 2012 Jan 17;7(1):e29865. doi: 10.1371/journal.pone.0029865

Figure 1. Expression of strong and weak forms of LTP and LTD in the basal and apical dendritic compartments of CA1 pyramidal neurons.

Figure 1

(A, B): A strong form of LTD that expressed the protein synthesis dependent late phase of LTD (L-LTD) was induced by paired pulses of low frequency stimulation (PP-1Hz: 50 msec interpulse interval at 1 Hz for 15 min) in the basal (A, dark gray circles, n = 6) and apical (B, dark gray circles, n = 6) dendritic compartments. Conversely, a weak form of LTD that expressed the protein synthesis independent early phase of LTD (E-LTD) was induced after a single train of low frequency stimulation (1 Hz: 1 train of 15 min at 1 Hz) in the basal (A, light gray circles, n = 5) and apical (A, light gray circles, n = 5) dendritic compartments. Blockage of new protein synthesis transformed strong LTD into weak LTD in the basal (A, open circles, n = 6) and apical (B, open circles, n = 6) dendritic compartments (anisomycin, an inhibitor of translation, was added between −20 min and +20 min of recording). (C, D): A strong form of LTP that expressed the late phase of LTP (L-LTP) was induced by 4 trains of high frequency stimulation (HFS, 4 trains of 1-sec at 100 Hz stimulation, 5 min inter-train interval) in the basal (C, dark gray circles, n = 6) and apical (D, dark gray circles, n = 6) dendritic compartments. Like with strong LTD, blockage of new protein synthesis transformed strong LTP into weak LTP that expressed the early phase of LTP in the basal (C, open circles, n = 6) and apical (D, open circles, n = 6) dendritic compartments (anisomycin was added between −20 min and +20 min of recording). S1 and S2 represent independent afferents synapsing on basal or apical dendrites, respectively.