Table 1. Differentially expressed genes in response to PGC-1α-overexpression in cultured muscle cells.
| RefSeq | Gene symbol | Gene description | FC | P value |
| Upregulated | ||||
| NM_002854.2 | PVALB | parvalbumin | +3.17 | 0.0049 |
| NM_001825.1 | CKMT2 | creatine kinase, mitochondrial 2 (sarcomeric) | +3.04 | 0.0220 |
| NM_000584.2 | IL8 | interleukin 8 | +3.02 | 0.0108 |
| NM_002993.2 | CXCL6 | chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) | +2.98 | 0.0068 |
| NM_002985.2 | CCL5 | chemokine (C-C motif) ligand 5 | +2.95 | 0.0017 |
| NM_005952.2 | MT1X | metallothionein 1X | +2.55 | 0.0034 |
| NM_001024466.1 | SOD2 | superoxide dismutase 2, mitochondrial | +2.39 | 0.0003 |
| NM_005623.2 | CCL8 | chemokine (C-C motif) ligand 8 | +2.25 | 0.0001 |
| NM_001151.2 | SLC25A4 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 | +2.25 | 8.89E-06 |
| NM_001677.3 | ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | +1.93 | 0.0003 |
| NM_002038.2 | G1P3 | Homo sapiens interferon, alpha-inducible protein (clone IFI-6-16) (G1P3) | +1.93 | 0.0194 |
| NM_020529.1 | NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | +1.92 | 0.0002 |
| NM_005954.2 | MT3 | metallothionein 3 | +1.89 | 0.0014 |
| NM_005530.2 | IDH3A | isocitrate dehydrogenase 3 (NAD+) alpha | +1.86 | 0.0241 |
| NM_001785.1 | CDA | cytidine deaminase | +1.86 | 0.0159 |
| NM_213720.1 | CHCHD10 | coiled-coil-helix-coiled-coil-helix domain containing 10 | +1.80 | 0.0147 |
| NM_032321.1 | C2orf88 | chromosome 2 open reading frame 88 | +1.75 | 0.0101 |
| NM_181679.1 | NFS1 | NFS1 nitrogen fixation 1 homolog (S. cerevisiae) | +1.73 | 0.0032 |
| NM_022153.1 | C10orf54 | chromosome 10 open reading frame 54 | +1.73 | 0.0002 |
| NM_022440.1 | MAL | mal, T-cell differentiation protein | +1.73 | 0.0036 |
| NM_181755.1 | HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | +1.72 | 0.0098 |
| NR_001561.1 | CYCS | cytochrome c, somatic | +1.71 | 0.0003 |
| NM_006114.1 | TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | +1.69 | 0.0002 |
| NM_213650.1 | SFXN4 | sideroflexin 4 | +1.69 | 0.0002 |
| NM_001629.2 | ALOX5AP | arachidonate 5-lipoxygenase-activating protein | +1.67 | 0.0027 |
| NM_005950.1 | MT1G | metallothionein 1G | +1.65 | 0.0184 |
| NM_002982.3 | CCL2 | chemokine (C-C motif) ligand 2 | +1.64 | 0.0110 |
| NM_016098.1 | BRP44L | brain protein 44-like | +1.64 | 0.0020 |
| NM_003155.2 | STC1 | stanniocalcin 1 | +1.63 | 0.0042 |
| NM_032231.4 | FAM96A | family with sequence similarity 96, member A | +1.63 | 0.0019 |
| NM_003039.1 | SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | +1.62 | 0.0067 |
| NM_198434.1 | AURKA | aurora kinase A | +1.60 | 0.0010 |
| NM_006528.2 | TFPI2 | tissue factor pathway inhibitor 2 | +1.60 | 0.0066 |
| NM_206963.1 | RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | +1.60 | 0.0051 |
| NM_004451.3 | ESRRA | estrogen-related receptor alpha | +1.60 | 0.0001 |
| NM_003000.1 | SDHB | succinate dehydrogenase complex, subunit B, iron sulfur (Ip) | +1.59 | 0.0024 |
| NM_001710.4 | CFB | complement factor B | +1.57 | 0.0119 |
| NM_203402.1 | FITM1 | fat storage-inducing transmembrane protein 1 | +1.57 | 0.0016 |
| NM_198594.1 | C1QTNF1 | C1q and tumor necrosis factor related protein 1 | +1.57 | 0.0003 |
| NM_014222.2 | NDUFA8 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19 kDa | +1.53 | 0.0003 |
| NM_004753.4 | DHRS3 | dehydrogenase/reductase (SDR family) member 3 | +1.53 | 0.0036 |
| NM_001218.3 | CA12 | carbonic anhydrase XII | +1.51 | 0.0120 |
| Downregulated | ||||
| NM_014059.1 | C13orf15 | chromosome 13 open reading frame 15 | −1.73 | 0.0024 |
| NM_002472.1 | MYH8 | myosin, heavy chain 8, skeletal muscle, perinatal | −1.64 | 0.0007 |
| NM_016300.4 | ARPP-21 | cyclic AMP-regulated phosphoprotein, 21 kD | −1.64 | 0.0094 |
| NM_006009.2 | TUBA1A | tubulin, alpha 1a | −1.62 | 0.0002 |
| NM_201525.1 | GPR56 | G protein-coupled receptor 56 (GPR56) | −1.61 | 0.0096 |
| NM_032645.3 | RAPSN | receptor-associated protein of the synapse | −1.59 | 0.0144 |
| NM_001031692.1 | LRRC17 | leucine rich repeat containing 17 | −1.56 | 0.0002 |
| NM_006888.2 | CALM1 | calmodulin 1 (phosphorylase kinase, delta) | −1.53 | 0.0008 |
| NM_000362.4 | TIMP3 | TIMP metallopeptidase inhibitor 3 | −1.52 | 0.0008 |
| NM_003068.3 | SNAI2 | snail homolog 2 (Drosophila) | −1.52 | 0.0036 |
| NM_003246.2 | THBS1 | thrombospondin 1 | −1.51 | 0.0003 |
Microarray analysis was performed on six cultured skm cell samples from three independent experiments, three transduced with Ad-GFP and three with Ad-PGC-1α adenovirus. The table lists the 53 regulated gene transcripts selected on the basis of the fold change (FC) and ordered by the magnitude of the absolute FC. Replicated genes, which occurred more than once in the microarray, were filtered: those appearing first in the list were arbitrarily chosen. The first column lists the NCBI Reference Sequence (RefSeq) accession number of the transcripts, the second the gene symbol, the third the description of the gene, the fourth the FC (with a positive symbol for upregulated genes and a negative symbol for downregulated ones) and the fifth the significance of differences as estimated by a paired t-test.