Table 1. Selected groups of genes regulated in Lrp5−/− retina.
| Genes: | Fold change in Lrp5−/− retina |
| Cell Adhesion/Junction | |
| claudin 5 (Cldn5) | (−) 8.97 |
| Von Willebrand factor homolog (Vwf) | (−) 2.56 |
| secreted phosphoprotein 1 (Spp1) | (−) 2.32 |
| CD93 antigen (CD93) | (−) 1.89 |
| procollagen, type XVIII, alpha 1 (Col18a1) | (−) 1.72 |
| endothelial cell-specific adhesion molecule (Esam1) | (−) 1.73 |
| endothelial-specific receptor tyrosine kinase (Tek) | (−) 1.48 |
| connective tissue growth factor (Ctgf) | (−) 1.55 |
| intercellular adhesion molecule 2 (Icam2) | (−) 1.31 |
| vinculin (Vcl) | (−) 1.29 |
| plasmalemma vesicle associated protein (Plvap) | (+) 1.78 |
| epithelial membrane protein 1 (EMP1) | (+) 2.08 |
| Membrane Transporter | |
| solute carrier family 38, member 5 (Slc38a5) | (−) 7.11 |
| major facilitator superfamily domain containing 2 (Mfsd2) | (−) 3.26 |
| solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1) | (−) 2.22 |
| gap junction membrane channel protein alpha 1 (Gja1) | (−) 2.05 |
| solute carrier family 3, member 4 (Slc3a4) | (−) 2.01 |
| solute carrier organic anion transporter family, member 2b1 (Slco2b1) | (−) 1.92 |
| receptor (calcitonin) activity modifying protein 2 (Ramp2) | (−) 1.53 |
| Blood vessel development/morphogenesis | |
| gap junction membrane channel protein alpha 1 (Gja1) | (−) 2.05 |
| procollagen, type XVIII, alpha 1 (Col18a1) | (−) 1.72 |
| endothelin receptor type A (Ednra) | (−) 1.49 |
| bone morphogenetic protein 4 (Bmp4) | (−) 1.42 |
| gap junction protein, alpha 4 (Gja4) | (−) 1.42 |
| EGF-like domain 7 (Egfl7) | (−) 1.38 |
| SRY-box containing gene 18 (Sox18) | (−) 1.38 |
Note: Retinas were isolated from P8 Lrp5−/− mice and age matched WT control mice. RNA was isolated and assessed with Illumina gene expression microarray. (−) indicates decreased expression in Lrp5−/− retina and (+) indicates increased expression in Lrp5−/− retina compared to WT control.