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. 2012 Jan 17;7(1):e30163. doi: 10.1371/journal.pone.0030163

Figure 9. Inhibition of calpain activity reversed the PrP106–126-induced destruction on microtubule structures and cytotoxicity.

Figure 9

A. SK-N-SH cells were treated with 200 µM of PrP 106–126 with or without calpain inhibitor ALLN for 12 h. Immunofluorescence images of cellular microtubule structure (upper) and morphological analyses of cells (lower) were shown. B. Cell viability after exposed to PrP106–126 with or without ALLN. The average data of each preparation was calculated based on three independent experiments and represented as mean ± S.D. Statistical differences are illustrated as P<0.05.