Figure 5. RGS5 deficiency promoted inflammation and JNK, NF-κB signaling in the adipose tissue, liver and skeletal muscle of mice fed an HF for 24 weeks.

A Expression levels of mRNA related to inflammation in the visceral adipose tissue of WT (a dotted line at value 1) and KO (black) mice (n = 6). B Expression levels of mRNA related to inflammation in the liver of WT (a dotted line at value 1) and KO (black) mice(n = 6). C Expression levels of mRNA related to inflammation in the gastrocnemius muscle of WT (a dotted line at value 1) and KO (black) mice (n = 6). D Phosphorylation levels of proteins related to inflammatory signaling in the visceral adipose tissue, liver and gastrocnemius muscle of KO and WT mice (n = 6). E Quantitative measurements of p-JNK, p-IκBα and p-NF-κBp65 protein relative to their total protein between WT mice (a dotted line at value 1) and KO mice (black). Values represent means ± SEM. *p<0.05 and **p<0.01 compared with WT mice.