Table 1. Effect of RGS5 deficiency on body weight at initial of feeding and body weight, mean food intake, fat and liver weight after 24 weeks of feeding (n = 8–10).
Variable | NC | HFD | ||
WT | KO | WT | KO | |
Body weight (initial) (g) | 23.82±0.19 | 24.41±0.32 | 24.74±0.32 | 24.39±0.31 |
Body weight (24 weeks) (g) | 31.86±0.57 | 38.33±0.83## | 45.24±1.11## | 50.28±0.99** |
Visceral fat weight (g) | 1.24±0.09 | 3.10±0.24## | 3.68±0.18## | 4.97±0.27** |
% Body weight | 3.89±0.27 | 8.03±0.49## | 8.10±0.22## | 9.89±0.49* |
Liver weight (g) | 1.34±0.04 | 1.64±0.08## | 1.87±0.11## | 2.54±0.09** |
% Body weight | 4.20±0.11 | 4.30±0.22 | 4.12±0.19 | 5.05±0.17** |
Food intake(kcal/mice/week) | 72.62±2.81 | 85.63±3.45## | 88.54±3.42## | 95.90±3.73 |
Data are means ± SEM.
p<0.01 vs. WT mice fed an NC;
*p<0.05 and
**p<0.01 vs. WT mice fed an HF.