Table 3. Metabolic and inflammatory variables in circulation after 24 weeks of feeding (n = 8).

Variable	NC		HFD
	WT	KO	WT	KO
FFA (mmol/l)	0.77±0.03	0.94±0.03##	1.12±0.05##	1.55±0.05**
TG (mg/dl)	41.35±1.72	44.60±1.86	50.54±2.10##	64.19±2.69**
TC (mg/dl)	135.30±5.69	145.19±6.08	255.19±10.76##	342.35±14.12**
HDL (mg/dl)	89.50±3.75	74.72±3.12##	74.20±3.11##	55.23±2.30**
LDL (mg/dl)	17.93±0.72	19.18±0.80	24.53±1.00##	32.88±1.33**
leptin (pg/ml)	5351.95±225.92	5531.80±233.29	12442.90±525.18##	16355.70±690.77**
resistin (pg/ml)	922.48±38.68	971.84±40.81	1310.94±54.49##	1552.38±65.34**
Adiponectin (ug/ml/g)	1.13±0.04	1.02±0.04#	0.57±0.02##	0.34±0.01**
IL-1β (pg/ml)	39.96±1.63	44.52±1.86	57.88±2.27##	69.86±2.86**
IL-2 (pg/ml)	13.95±0.55	14.61±0.40	17.29±0.72##	19.19±0.79*
IL-6 (pg/ml)	0.73±0.02	0.92±0.04##	1.21±0.03##	1.66±0.07**
TNF-α (pg/ml)	2.88±0.10	2.76±0.10	3.66±0.12##	5.13±0.21**
MCP-1 (pg/ml)	24.21±0.99	22.55±0.70	29.68±1.17##	39.59±1.65**

Data are means ± SEM.

^# p<0.05 and

^## p<0.01 vs. WT mice fed an NC;

*p<0.05 and

**p<0.01 vs. WT mice fed an HF.