Figure 4. Schematic illustration of MOS effects on glucose metabolism between control and LPS-challenged hosts.

(i) LPS triggered no major intestinal metabolic activities; (ii) in absence of glucose mobilization, liver glucose uptake and transport were repressed by DIO2 down-regulation and KCNA3 up-regulation, respectively; (iii) glycolysis and glycogen synthesis were coordinately reduced by ENO2 and UGP2 down-regulation, respectively; (iv) CS up-regulation increased TCA-derived energy from high liver pyruvate; (v) PRKAG2 up-regulation inhibited fatty acid and cholesterol biosynthesis.