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. 2012 Jan 17;7(1):e30323. doi: 10.1371/journal.pone.0030323

Table 1. Genes identified as differentially expressed due to main LPS effects1.

Gene Gene symbol Gene ID Fold change P-value Gene regulation by LPS2
Intestine
Immune response
Interleukin 3 IL-3 474356 1.03 0.00328 +
Toll-like receptor 2 precursor TLR2-2 769014 0.98 0.00596
Zinc finger CCCH-type containing 15 ZC3H15 423992 0.98 0.03575
2′–5′ oligoadenylate synthetase A OAS*A 395908 0.96 0.02579
Gallinacin-1 alpha Gal-1 395841 0.99 0.09106
Metabolism
Phosphoenolpyruvate carboxykinase 1 PEPCK 396458 1.05 0.00497 +
Phosphopyruvate hydratase ENO2 395689 0.94 0.00018
3-hydroxy-3-methylglutaryl-CoA reductase HMGCR 395145 0.95 0.00004
Others
Myosin, heavy polypeptide 7, cardiac muscle MYH7 395350 1.03 0.01938 +
Actin alpha 2, smooth muscle, aorta ACTA2 423787 0.98 0.04217
Myosin light polypeptide 9 regulatory MYL9 396215 1.04 0.02469 +
Liver
Immune response
Signal transducer and activator of transcription 2 STAT2 6773 1.04 0.00018 +
Putative CXCR1 isoform I and II (IL-8 receptor) CXCR1 430652 0.97 0.02406
Metabolism
Enoyl-CoA hydratase EHHADH 424877 1.05 0.00017 +
Protein phosphatase 1 PPP1R8 419564 1.03 0.00818 +
Malic enzyme 1 ME 374189 1.03 0.03684 +
5′-AMP-activated protein kinase gamma-2 PRKAG2 420435 1.03 0.00190 +
Others
Deiodinase Type 2 DIO2 373903 0.95 0.00043
Iroquois homeobox protein 1 IRX1 374185 1.05 0.00136 +
Potassium voltage-gated channel shaker-related subfamily No 3 KCNA3 404303 1.06 0.00008 +
Skeletal muscle
Metabolism
6-phosphofructokinase (PFK-1) PFKM 374064 0.95 0.00001
Others
Atrial natriuretic factor precursor NPPA 395765 1.03 0.00005 +
1

Pooled LPS-challenged hosts: MOS+VIRG (antibiotic) groups; The complete raw data have been deposited in the Gene Expression Omnibus (GEO) database, www.ncbi.nlm.nih.gov/projects/geo (accession no. GSE28959).

2

+: up-regulated genes by LPS; −: down-regulated genes by LPS.