Table 1. Genes identified as differentially expressed due to main LPS effects1.
Gene | Gene symbol | Gene ID | Fold change | P-value | Gene regulation by LPS2 |
Intestine | |||||
Immune response | |||||
Interleukin 3 | IL-3 | 474356 | 1.03 | 0.00328 | + |
Toll-like receptor 2 precursor | TLR2-2 | 769014 | 0.98 | 0.00596 | − |
Zinc finger CCCH-type containing 15 | ZC3H15 | 423992 | 0.98 | 0.03575 | − |
2′–5′ oligoadenylate synthetase A | OAS*A | 395908 | 0.96 | 0.02579 | − |
Gallinacin-1 alpha | Gal-1 | 395841 | 0.99 | 0.09106 | − |
Metabolism | |||||
Phosphoenolpyruvate carboxykinase 1 | PEPCK | 396458 | 1.05 | 0.00497 | + |
Phosphopyruvate hydratase | ENO2 | 395689 | 0.94 | 0.00018 | − |
3-hydroxy-3-methylglutaryl-CoA reductase | HMGCR | 395145 | 0.95 | 0.00004 | − |
Others | |||||
Myosin, heavy polypeptide 7, cardiac muscle | MYH7 | 395350 | 1.03 | 0.01938 | + |
Actin alpha 2, smooth muscle, aorta | ACTA2 | 423787 | 0.98 | 0.04217 | − |
Myosin light polypeptide 9 regulatory | MYL9 | 396215 | 1.04 | 0.02469 | + |
Liver | |||||
Immune response | |||||
Signal transducer and activator of transcription 2 | STAT2 | 6773 | 1.04 | 0.00018 | + |
Putative CXCR1 isoform I and II (IL-8 receptor) | CXCR1 | 430652 | 0.97 | 0.02406 | − |
Metabolism | |||||
Enoyl-CoA hydratase | EHHADH | 424877 | 1.05 | 0.00017 | + |
Protein phosphatase 1 | PPP1R8 | 419564 | 1.03 | 0.00818 | + |
Malic enzyme 1 | ME | 374189 | 1.03 | 0.03684 | + |
5′-AMP-activated protein kinase gamma-2 | PRKAG2 | 420435 | 1.03 | 0.00190 | + |
Others | |||||
Deiodinase Type 2 | DIO2 | 373903 | 0.95 | 0.00043 | − |
Iroquois homeobox protein 1 | IRX1 | 374185 | 1.05 | 0.00136 | + |
Potassium voltage-gated channel shaker-related subfamily No 3 | KCNA3 | 404303 | 1.06 | 0.00008 | + |
Skeletal muscle | |||||
Metabolism | |||||
6-phosphofructokinase (PFK-1) | PFKM | 374064 | 0.95 | 0.00001 | − |
Others | |||||
Atrial natriuretic factor precursor | NPPA | 395765 | 1.03 | 0.00005 | + |
Pooled LPS-challenged hosts: MOS+VIRG (antibiotic) groups; The complete raw data have been deposited in the Gene Expression Omnibus (GEO) database, www.ncbi.nlm.nih.gov/projects/geo (accession no. GSE28959).
+: up-regulated genes by LPS; −: down-regulated genes by LPS.