Table 4. Genes identified as differentially expressed due to LPS within antibiotic-fed hosts1.
| Gene | Gene symbol | Gene ID | Fold change | P-value | Gene regulation by LPS2 |
| Intestine | |||||
| Immune response | |||||
| Interleukin 3 | IL-3 | 474356 | 1.04 | 0.00404 | + |
| Toll-like receptor 3 | TLR3 | 422720 | 1.03 | 0.01264 | + |
| 2′–5′-oligoadenylate synthetase A | OAS*A | 395908 | 1.13 | 0.00000 | + |
| Metabolism | |||||
| Phosphoenolpyruvate carboxykinase 1 | PEPCK | 396458 | 1.12 | 0.00002 | + |
| Phosphopyruvate hydratase | ENO2 | 395689 | 0.94 | 0.01255 | − |
| 3-hydroxy-3-methylglutaryl-CoA reductase | HMGCR | 395145 | 0.95 | 0.00369 | − |
| Others | |||||
| Myosin, heavy polypeptide 7, cardiac muscle | MYH7 | 395350 | 1.03 | 0.04746 | + |
| Myosin, heavy chain 11, smooth muscle | MYH11 | 396211 | 0.92 | 0.00094 | − |
| Atrial natriuretic factor precursor | NPPA | 395765 | 1.03 | 0.00679 | + |
| Iron regulatory protein 1 | IRP1 | 373916 | 0.96 | 0.02641 | − |
| Liver | |||||
| Metabolism | |||||
| ATP citrate lyase | ACLY | 395373 | 1.04 | 0.04584 | + |
| Phosphopyruvate hydratase | ENO2 | 395689 | 1.05 | 0.00869 | + |
| Malic enzyme 1 | ME | 374189 | 1.06 | 0.01385 | + |
| ATP citrate synthase | CS | 1431 | 0.96 | 0.03024 | − |
| Skeletal muscle | |||||
| Metabolism | |||||
| 6-phosphofructokinase (PFK-1) | PFKM | 374064 | 0.95 | 0.00246 | − |
| Others | |||||
| Atrial natriuretic factor precursor | NPPA | 395765 | 1.03 | 0.00416 | + |
1
Hosts fed antibiotic (VIRG): LPS-challenged v/s non-challenged controls; The complete raw data have been deposited in the Gene Expression Omnibus (GEO) database, www.ncbi.nlm.nih.gov/projects/geo (accession no. GSE28959).
2
+: up-regulated genes by LPS; −: down-regulated genes by LPS.