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. 2012 Jan 17;7(1):e30304. doi: 10.1371/journal.pone.0030304

Figure 2. VU0183254 reduces OR-mediated currents.

Figure 2

A–B. Whole-cell patch clamp recordings of odorant- and VUAA1-induced currents in AgOr-expressing cells (n = 3). A. VU0183254 (100 µM) decreased responses to delta-undecalactone (1 µM) and VUAA1 (100 µM) in HEK cells expressing AgOrco+AgOr48. B. Responses to eugenol (1 µM) and VUAA1 (100 µM) in AgOrco+AgOr65 cells were reduced by VU0183254 (100 µM). C–D. Cells expressing Orco from either An. gambiae (C) or Harpegnathos saltator (D) had reduced VUAA1 (100 µM) currents in the presence of 100 µM VU0183254. E. Capsaicin (10 µM) currents in HEK cells expressing rat TRPVI were not reduced with by 100 µM VU0183254. Holding potential for all figures is −60 mV.