Table 3.
Complex II + III activity (nmol/min × mg) in tissue mitochondria from 3-, 12-, and 20-month old Ames dwarf and wild-type mice
| Genotype | Dwarf | Wild-type | Dwarf | Wild-type | Dwarf | Wild-type | P value | ||
|---|---|---|---|---|---|---|---|---|---|
| Age | 3 Months | 3 Months | 12 Months | 12 Months | 20 Months | 20 Months | Genotype | Age | Interaction |
| Liver | 107.2 ± 8.2 | 105.2 ± 5.6 | 111.5 ± 11.8 | 85.6 ± 15.1 | 102.7 ± 13.9 | 113.9 ± 12.3 | 0.5735 | 0.6862 | 0.2893 |
| Kidney | 194.2 ± 6.1 | 188.1 ± 17.7 | 155.7 ± 10.0 | 145.2 ± 11.9 | 254.6 ± 17.3 | 178.6 ± 12.1 | 0.0066 | <0.0001 | 0.0204 |
| Skeletal muscle | 65.0 ± 4.8 | 139.8 ± 19.5 | 105.9 ± 11.5 | 142.4 ± 22.3 | 84.5 ± 8.2 | 98.1 ± 10.2 | 0.0012 | 0.0861 | 0.1204 |
Values represent mean ± SEM. P values represent results of a two-way ANOVA. n = 7–8/genotype/age