Table 3.
Oxidative metabolism
| Testosterone | Placebo | |||||
|---|---|---|---|---|---|---|
| Start | 3 months | 6 months | Start | 3 months | 6 months | |
| Basal GOX (mg/min/m2) |
50.9 (43.2–65-1) | 45.6 (38.3–51.5)* | 41.3 (33.6–49.7)* | 54.8 (47.1–61.9) | 57.6 (43.7–65.0) | 55.6 (41.7–58.9) |
| Basal LOX (mg/min/m2) | 25.2 ± 11.8 | 31.7 ± 7.6 | 31.8 ± 7.0* | 28.1 ± 8.3 | 28.0 ± 10.2 | 26.7 ± 9.3 |
| Basal RQ | 0.84 ± 0.05 | 0.81 ± 0.02* | 0.80 ± 0.03* | 0.83 ± 0.03 | 0.83 ± 0.04 | 0.83 ± 0.03 |
| Insulin-stimulated GOX (mg/min/m2) |
95.0 (73.6–129.4) | 112.4 (84.7–124.6) | 92.4 (81.5–110.9) | 114.5 (83.8–136.5) | 110.7 (94.0–124.9) | 106.0 (86.9–124.6) |
| Insulin-stimulated LOX (mg/min/m2) |
12.2 (2.1–17.5) | 10.7 (6.4–20.4) | 14.3 (8.3–18.6) | 6.5 (1.6–13.0) | 7.3 (2.4–14.7) | 5.4 (20.1–14.6) |
| Insulin-stimulated RQ (clamp) | 0.92 ± 0.07 | 0.91 ± 0.04 | 0.90 ± 0.05 | 0.93 ± 0.05 | 0.93 ± 0.06 | 0.94 ± 0.06 |
Values are given as mean ± SD or median (interquartile range) as appropriate
LOX lipid oxidation, GOX glucose oxidation, RQ respiratory quotient
*p < 0.05 compared to placebo; **p < 0.01 compared to placebo