Table 4.
Association between thyroid axis parameters and whole-blood LPS-stimulated cytokine production in subjects aged 85
| Change per standard deviation increase | |||
|---|---|---|---|
| LPS -stimulated cytokine levels | ln Thyrotropin (mU/L) | Free thyroxine (pmol/L) | Free triiodothyronine (pmol/L) |
| ln IL-1β (ng/ml) | −0.06 (0.05) | 0.03 (0.05) | 0.09 (0.04) |
| p value | 0.24 | 0.47 | 0.047 |
| ln IL-6 (ng/ml) | −0.02 (0.03) | 0.01 (0.03) | 0.06 (0.03) |
| p value | 0.48 | 0.82 | 0.017 |
| ln TNF-α (ng/ml) | −0.03 (0.03) | 0.02 (0.03) | 0.07 (0.03) |
| p value | 0.37 | 0.46 | 0.006 |
| ln IL1β RA (ng/ml) | 0.00 (0.03) | 0.02 (0.03) | 0.01 (0.02) |
| p value | 0.99 | 0.35 | 0.58 |
| ln IL-10 (ng/ml) | −0.03 (0.05) | −0.02 (0.04) | 0.03 (0.04) |
| p value | 0.51 | 0.60 | 0.41 |
Data are given as mean change (with standard error of the mean) in LPS stimulated cytokine level per standard deviation increase in serum thyroid parameter
All analyses were adjusted for sex, ADLs, instrumental ADLs, MMSE, and log serum CRP levels
LPS lipopolysaccharide