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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Psychopharmacology (Berl). 2011 Jul 16;219(3):823–834. doi: 10.1007/s00213-011-2409-y

Figure 6. Paradoxical effects of NMDA receptor blockade in mice lacking Gβ5.

Figure 6

Gβ5−/−mice or their wild-type littermates (n=5) were injected either with saline or various doses of MK-801 and their ambulatory activities were monitored in the open field chamber. The same subjects were used to test the different MK-801doses with 2 days allowed between treatments. ANOVA revealed a significant effect of MK-801 on activity of both Gβ5+/+ (F(4,29) = 6.896, p < 0.001) and Gβ5−/− (F(4,29) = 34.921, p < 0.001) mice. Pairwise post hoc Tukey’s test revealed significant differences between treatments and saline control when indicated (*p < 0.05; **p < 0.01). Error bars represent SEMs.